1. N. Momin, S. Pabel, A. Rudra, N. Kumowski, I.-H. Lee, K. Mentkowski, M. Yamazoe, L. Stengel, C. G. Muse, H. Seung, A. Paccalet, C. Gonzalez-Correa, E. Jacobs, J. Grune, M. J. Schloss, S. Sossalla, G. Wojtkiewicz, Y. Iwamoto, P. McMullen, R. N. Mitchell, P. T. Ellinor, D. G. Anderson, K. Naxerova, M. Nahrendorf, M. Hulsmans, Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillation. bioRxiv, https://doi.org/10.1101/2024.08.10.607461. (2024).

  2. N. Momin. Balancing safety and efficacy: tuning the biodistribution and pharmacokinetics of cytokine immunotherapies. Current Opinion in Biotechnology. 84 (2023). https://doi.org/10.1016/j.copbio.2023.102994. (IF = 10.3)

Publications Prior to Penn

First & Co-First Author Publications

  1. N. Momin, N. K. Mehta, N. R. Bennett, L. Ma, J. R. Palmeri, M. M. Chinn, E. A. Lutz, B. Kang, D. J. Irvine, S. Spranger, K. D. Wittrup. Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy. Science Translational Medicine. 11 (2019). https://doi.org/10.1126/scitranslmed.aaw2614. (IF = 17.2)

  2. N. Momin, J. R. Palmeri, E. A. Lutz, N. Jailkhani, H. Mak, A. Tabet, M. M. Chinn, B. Kang, V. Spanoudaki, R. O. Hynes, K. D. Wittrup. Maximizing response to intratumoral immunotherapy in mice by tuning local retention. Nature Communications. 13, 109 (2022). https://doi.org/10.1038/s41467-021-27390-6. (IF = 14.9)

  3. E. A. Lutz*, N. Jailkhani*, N. Momin*, Y. Huang, A. M. Sheen, B. Kang, R.O. Hynes, K. D. Wittrup. Intratumoral nanobody-IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice. PNAS Nexus. gac244 (2022). *co-first author; https://doi.org/10.1093/pnasnexus/pgac244.(IF = 12.8)

  4. N. Momin, S. Lee, A. K. Gadok, D. J. Busch, G. D. Bachand, C. C. Hayden, J. C. Stachowiak, D. Y. Sasaki. Designing lipids for selective partitioning into liquid ordered membrane domains. Soft Matter. 11, 3241–3250 (2015). https://doi.org/10.1039/C4SM02856B. (IF = 4.1)

Co-Author Publications

  1. N. K. Mehta, K. Rakhra, K. A. Meetze, B. Li, N. Momin, J. Y. H. Chang, K. D. Wittrup, P. A. Baeuerle, J. S. Michaelson, CLN-617 retains IL2 and IL12 in injected tumors to drive robust and systemic immune-mediated antitumor activity. Cancer Immunology Research. 12, 1022–1038 (2024). https://doi.org/10.1158/2326-6066.CIR-23-0636. (IF = 8.1)

  2. J. A. Stinson, M. M. P. Barbosa, A. Sheen, N. Momin, E. Fink, J. Hampel, K. Selting, R. Kamerer, K. L. Bailey, K. D. Wittrup, T. M. Fan, Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs, bioRxiv. (2024). https://doi.org/10.1101/2024.02.12.579965.

  3. N. Hegemann, P. Sang, J. H. Kim, C. Koçana, N. Momin, J. Klages, M. M. Kucherenko, C. Knosalla, B. O’Brien, S. Simmons, M. Nahrendorf, W. M. Kuebler, J. Grune, Ultrasonographic assessment of pulmonary and central venous congestion in experimental heart failure. Am. J. Physiol. Heart Circ. Physiol. 326, H433–H440 (2024). https://doi.org/10.1152/ajpheart.00735.2023.(IF = 4.1)

  4. J. A. Stinson*, A. Sheen*, N. Momin, J. Hampel, R. Bernstein, R. Kamerer, B. Fadl-Alla, J. Samuelson, E. Fink, T. M. Fan, K. D. Wittrup, Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft-tissue sarcomas. Clinical Cancer Research. 29, 2110–2122 (2023). *co-first author. https://doi.org/10.1158/1078-0432.CCR-23-0006.(IF = 10.4)

  5. M. Hulsmans*, M. J. Schloss*, I.-H. Lee*, A. Bapat, Y. Iwamoto, C. Vinegoni, A. Paccalet, M. Yamazoe, J. Grune, S. Pabel, N. Momin, H. Seung, N. Kumowski, F. E. Pulous, D. Keller, C. Bening, U. Green, J. K. Lennerz, R. N. Mitchell, A. Lewis, B. Casadei, O. Iborra-Egea, A. Bayes-Genis, S. Sossalla, C. S. Ong, R. N. Pierson, J. C. Aster, D. Rohde, G. R. Wojtkiewicz, R. Weissleder, F. K. Swirski, G. Tellides, G. Tolis Jr, S. Melnitchouk, D. J. Milan, P. T. Ellinor, K. Naxerova, M. Nahrendorf, Recruited macrophages elicit atrial fibrillation. Science. 381, 231–239 (2023). *co-first author. https://doi.org/10.1126/science.abq3061. (IF = 44.7)

  6. M. Zagorulya, L. Yim, D. M. Morgan, A. Edwards, E. Torres-Mejia, N. Momin, C. V. McCreery, I. L. Zamora, B. L. Horton, J. G. Fox, K. D. Wittrup, J. C. Love, S. Spranger, Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer. Immunity. 56, 386-405.e10 (2023). https://doi.org/10.1016/j.immuni.2023.01.010.(IF = 25.5)

  7. B. L. Horton, A. D. D’Souza, M. Zagorulya, C. V. McCreery, G. C. Abhiraman, L. Picton, A. Sheen, Y. Agarwal, N. Momin, K. D. Wittrup, F. M. White, K. C. Garcia, S. Spranger, Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2. JCI Insight. 8 (2023). https://doi.org/10.1172/jci.insight.172728. (IF = 6.3)

  8. E. A. Lutz, Y. Agarwal, N. Momin, S.C. Cowles, J.R. Palmeri, E. Duong, V. Hornet, A. Sheen, B.M. Lax, A.M. Rothschilds, D.J. Irvine, S. Spranger, K.D. Wittrup. Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies. Proc. Natl. Acad. Sci. U.S.A. 119 (2022). https://doi.org/10.1073/pnas.2205983119. (IF=11.2)

  9. F. E. Pulous, J. C. Cruz-Hernández, C. Yang, Z. Kaya, A. Paccalet, G. Wojtkiewicz, D. Capen, D. Brown, J. W. Wu, M. J. Schloss, C. Vinegoni, D. Richter, M. Yamazoe, M. Hulsmans, N. Momin, J. Grune, D. Rohde, C. S. McAlpine, P. Panizzi, R. Weissleder, D. Kim, F. K. Swirski, C. P. Lin, M. A. Moskowitz, M. Nahrendorf. Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis. Nature Neuroscience. 25(5):567-576 (2022). https://doi.org/10.1038/s41593-022-01060-2. (IF = 24.8)

  10. B. Horton, D. Morgan, N. Momin, M. Zagorulya, E. Torres-Mejia, V. Bhandarkar, K.D. Wittrup, C.J. Love, S. Spranger. Lack of CD8 + T cell effector differentiation during priming mediates checkpoint blockade resistance in non-small cell lung cancer. Science Immunology. 6(64):eabi8800 (2021). https://doi.org/10.1126/sciimmunol.abi8800. (IF = 13.4)

  11. B.K. Kang, N. Momin, K. D. Moynihan, M. Silva, Y. Li, D.J. Irvine, K.D. Wittrup. Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice. PLoS One. 16(4) e0248903. (2021). https://doi.org/10.1371/journal.pone.0248903. (IF = 3.2)

  12. Y. Li, Z. Su, W. Zhao, X. Zhang, N. Momin, C. Zhang, K. D. Wittrup, Y. Dong, D. J. Irvine, R. Weiss. Multifunctional oncolytic nanoparticles carrying therapeutic self-replicating RNA eliminate established tumors and prime systemic immunity. Nature Cancer. (2020). https://doi.org/10.1038/s43018-020-0095-6. (IF = 53.1)

  13. N. Mehta, R. Pradhan, A. Soleimany, K. D. Moynihan, A. M Rothschilds, N. Momin, K. Rakhra, J. Mata-Fink, S. Bhatia, K. D. Wittrup, D. J. Irvine. Pharmacokinetic tuning of protein-antigen fusions to enhance the potency of therapeutic T cell vaccines. Nature Biomedical Engineering. (2020). https://doi.org/10.1038/s41551-020-0563-4. (IF = 25.7)

  14. Y. J. Xie, M. Dougan, J. R. Ingram, N. Pishesha, T. Fang, N. Momin, H. L. Ploegh. Improved Antitumor Efficacy of Chimeric Antigen Receptor T Cells that Secrete Single-Domain Antibody Fragments. Cancer Immunology Research. 8, 518–529 (2020). https://doi.org/10.1158/2326-6066.CIR-19-0734. (IF = 8.7)

  15. D. Dréau, L. J. Moore, M. Wu, L. D. Roy, L. Dillion, T. Porter, R. Puri, N. Momin, K. D. Wittrup, P. Mukherjee. Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology. 9, 330 (2019). https://doi.org/10.3389/fonc.2019.00330. (IF = 6.2)

  16. Y.J. Xie, M. Dougan, N. Jailkhani, J. Ingram, T. Fang, L. Kummer, N. Momin, N. Pishesha, S. Rickelt, R.O. Hynes, H. Ploegh. Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. Proc. Natl. Acad. Sci. U.S.A. 116, 7624–7631 (2019). https://doi.org/10.1073/pnas.1817147116. (IF = 11.2)

  17. B. H. Kwan, E. F. Zhu, A. Tzeng, H. R. Sugito, A. A. Eltahir, B. Ma, M. K. Delaney, P. A. Murphy, M. J. Kauke, A. Angelini, N. Momin, N. K. Mehta, A. M. Maragh, R. O. Hynes, G. Dranoff, J. R. Cochran, K. D. Wittrup. Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses. Journal of Experimental Medicine. 214, 1679–1690 (2017). https://doi.org/10.1084/jem.20160831. (IF = 14.3)

  18. C. S. Scheve, P. A. Gonzales, N. Momin, J. C. Stachowiak. Steric pressure between membrane-bound proteins opposes lipid phase separation. Journal of the American Chemical Society. 135, 1185–1188 (2013). https://doi.org/10.1021/ja3099867. (IF = 11.4)